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Rezultati farmakokinetičkih studija potencijalnih interakcija diazepama i antiepileptika su oprečni. Prijavljene su i snižene i povišene, ali i nepromenjene vrednosti koncentracije lekova u krvi.S obzirom na to da je rizik od pojave fenomena obustave/rebound fenomena veći ukoliko se terapija naglo prekine, preporučuje se postepeno smanjivanje
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